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Nucynta | Tapentadol Hydrochloride

Brand Name : Pentadol
Composition :Tapentadol Hydrochloride 50, 75, 100 mg
Manufactured by : Square Pharmaceuticals Ltd.
Form : Tablet
Packing : Pack of 100 Tablets

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Buy Nucynta online, Buy Tapentadol online.

Tapentadol known as Nucynta is an opioid pain medication that is used to help relieve moderate to severe short-term pain. NUCYNTA ER exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient’s risk prior to prescribing NUCYNTA ER, and monitor all patients regularly for the development of these behaviors and conditions. Buy Nucynta online


Tapentadol is a centrally-acting synthetic analgesic. It is 18 times less potent than morphine in terms of binding to human mu-opioid receptors. It also increases norepinephrine concentrations in the brains of rats via inhibition of norepinephrine reuptake. Oxymorphone 10 mg

Selective mu-opioid antagonists like naloxone can block analgesia from tapentadol / Nucynta. It also has no effect on the QT interval.

Tapendadol / Nucynta causes large increases in levels of extracellular norepinephrine (NE) due to a dual mechanism of action involving mu-opioid receptor (MOR) agonist as well as noradrenaline reuptake inhibition.

Dosage & Administration

As with many centrally-acting analgesic medications, the dosing regimen should be individualized according to the severity of pain being treated, the previous experience with similar drugs and the ability to monitor the patient.

The dose is 50 mg, 75 mg, or 100 mg every 4 to 6 hours depending upon pain intensity. On the first day of dosing, the second dose may be administered as soon as one hour after the first dose, if adequate pain relief is not attained with the first dose.

Subsequent dosing is 50 mg, 75 mg, or 100 mg every 4 to 6 hours and should be adjusted to maintain adequate analgesia with acceptable tolerability. Daily doses greater than 700 mg on the first day of therapy and 600 mg on subsequent days have not been studied and are not recommended.Uncategorized


Increased risk of serotonin syndrome with other drugs that enhance monoaminergic neurotransmission (e.g. TCAs, triptans, SSRIs, serotonin and norepinephrine reuptake inhibitors). Enhanced sedative effect with benzodiazepines, barbiturates, antipsychotics. Buy Nucynta online

Increased potential for addiction with mixed μ-opioid agonists/antagonists (e.g. nalbuphine, pentazocine) or partial μ-opioid agonists (e.g. buprenorphine). Increased systemic exposure with strong inhibitors of UGT1A6, UGT1A9, and UGT2B7 isoenzymes.


This drug is contraindicated in patients with impaired Pulmonary Function, It is also contraindicated in patients with acute or severe bronchial asthma or hypercapnia in unmonitored settings or the absence of resuscitative equipment.

Side Effects

The following treatment-emergent adverse events may happen: heart rate increased, heart rate decreased, visual disturbance, abdominal discomfort, impaired gastric emptying, irritability, edema, drug withdrawal syndrome, hypersensitivity, involuntary muscle contractions, sensation.

Pregnancy & Lactation

Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. This preparation should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Neonates whose mothers have been taking Tapentadol/Nucynta should be monitored for respiratory depression.

Precautions & Warnings

Tapentadol / Nucynta should be administered with caution to patients with conditions accompanied by hypoxia, hypercapnia respiratory problems such as asthma, chronic obstructive pulmonary disease etc.

Besides this in the case of patients with sleep apnea syndrome, myxedema, kyphoscoliosis, central nervous system (CNS) depression should have to be cautious prior to administration of Tapentadol.

Patients receiving other mu-opioid agonist analgesics, general anesthetics, phenothiazines, other tranquilizers, sedatives, hypnotics, or other CNS depressants (including alcohol) concomitantly with Tapentadol may exhibit additive CNS depression.

Use in Special Populations

Pediatric use: The safety and effectiveness of Tapentadol/Nucynta in pediatric patients less than 18 years of age have not been established.

Use in elderly patients: In general, the recommended dose for elderly patients with normal renal and hepatic function is the same as for younger adult patients with normal renal and hepatic function.

Use in Renal Disease: In patients with severe renal impairment, the safety and effectiveness of Tapentadol has not been established.

Use in Hepatic Disease: Tapentadol/Nucynta should be used with caution in patients with moderate hepatic impairment. Tapentadol has not been studied in patients with severe hepatic impairment.

Overdose Effects

Symptoms: Vomiting, miosis, CV collapse, consciousness disorders up to coma, convulsions, and resp depression up to resp arrest.

Management: Re-establish a patent airway and institute assisted or controlled ventilation. GI decontamination with activated charcoal or by gastric lavage may be considered within 2 hr after intake.

Storage Conditions

Store in a cool and dry place, protected from light and moisture. Keep the medicine out of the reach of children. Buy Nucynta online


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