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Midazolam, under the trade name Versed, among others, is a benzodiazepine medication used for anesthesia, procedural sedation, trouble sleeping, and severe agitation. buy midazolam online
Insomnia treatment for the short term. Sedation before or during diagnostic, therapeutic, or endoscopic operations such as dentistry, upper gastrointestinal endoscopy, bronchoscopy, cystoscopy, coronary angiography, and cardiac catheterization, oncology procedures, radiologic procedures, suturing of lacerations, and so on. buy midazolam online
And surgery performed under local anesthesia, either alone or in combination with other CNS depressants. Green Xanax bars online
- Induction of general anesthesia
- Sedation in intensive care
- Sedation in general anesthesia
- Status epilepticus.
Benzodiazepine hypnotics, Benzodiazepine sedatives
Midazolam/versed binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron at several sites w/in the CNS, including the limbic system, reticular formation. Enhancement of the inhibitory effect of GABA on neuronal excitability results from increased neuronal membrane permeability to Cl ions, which results in hyperpolarisation (a less excitable state) and stabilization. Benzodiazepine receptors and effects appear to be linked to the GABA-A receptors. Oxymorphone 10 mg
Dosage & Administration
The duration of treatment with oral midazolam/ versed should not be more than 2 weeks. In certain cases, extension beyond the maximum treatment period may be necessary.
- Adults: 7.5 mg to 15 mg daily (Oral)
- Elderly: 7.5 mg daily (Oral)
- Premedication: 7.5 mg to 15 mg, should be given 30-60 minutes before the procedure (Oral)
Endoscopic or Cardiovascular procedures:
- Adult: initial dose is 2.5 mg (IV)
- Elderly & debilitated patients: 1-1.5 mg (IV)
- Induction of Anesthesia: Adult: 10-15 mg (IV) or 0.07-0.1 mg/Kg body weight, usually 5 mg (IM)
- Children: 0.15-0.20 mg/Kg (IM)
- Elderly & debilitated patients: 0.025-0.05 mg/Kg (IM)
Rectal administration in children: for preoperative sedation, rectal administration of the ampoule solution is 0.35-0.45 mg/Kg, 20-30 min before induction of general anesthesia
CNS depressants, erythromycin, azole type antimycotics, and cimetidine may interact with Midazolam. Morphine Sulfate
Known hypersensitivity to versed or other benzodiazepines, severe respiratory insufficiency, severe hepatic insufficiency, sleep apnea syndrome, myasthenia gravis, patients with a history of alcohol or drug abuse, and children. buy midazolam online
The most prevalent side effect is drowsiness. CNS depression, ataxia, disorientation, weariness, muscle weakness, exhaustion, headache, dizziness, and double vision are less typical adverse effects. These side effects are more common at the beginning of treatment and normally go away once the dose is adjusted or the treatment is continued.
Pregnancy & Lactation
Insufficient data are available on versed to assess its safety during pregnancy. But benzodiazepines adversely affect the human fetus. So, their use should be avoided if there is a safer alternative. Midazolam is excreted through breast milk. Therefore, Midazolam should not be used by nursing mothers.
Precautions & Warnings
CNS depressants, erythromycin, azole type antimycotics, and cimetidine may interfere with the metabolism of versed. So, caution should be taken during the concomitant treatment with these drugs along with Midazolam. Long-time use of versed may increase dependency. As versed is a strong sedative, it should not be taken before driving or other performance skilled tasks. buy midazolam online
Drowsiness is the most common side effect. Less common side effects are CNS depression, ataxia, confusion, tiredness, muscle weakness, fatigue, headache, dizziness and double vision. These effects occur predominantly at the start of treatment and usually disappear with dose adjustment or continuation of therapy. buy midazolam online
Known hypersensitivity to Midazolam or other benzodiazepines, severe respiratory insufficiency, severe hepatic insufficiency, sleep apnea syndrome, myasthenia gravis, patients with a history of alcohol or drug abuse, and children.
versed should not be used more than the dosage guideline. Overdosage produces severe depression ranging from drowsiness to coma.
Protect from light and moisture, store in cool and dry place. Keep out of the reach of children.